气道平滑肌是维持气道张力的根本。它存在于气管、支气管树直至终末支气管。其特异的超微结构特点和调节机制是实现气管正常生理功能的基础。有证据表明气管平滑肌在肺的发育过程以及诸如**病、慢性支气管炎和肺气肿等疾病状态下经历着显著的表型变化。另外，气道平滑肌通过分泌细胞因子和趋化因子等促炎介质，发挥免疫调节功能。培养的气管平滑肌细胞能表达三种P21活化的激酶（PAK）的同型异构体和PAK1，并通过P38 mapk信号途径参与气管平滑肌细胞的迁移。气道平滑肌细胞增殖已成为人们关注的焦点，因为在**病人中，此细胞是气道壁重塑反应中数量上的重要组分，并被认为是新型抗**病药物的作用目标。
人气管平滑肌细胞提取于人气管组织，二代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过对alpha-SMA和Desmin免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。? ?
推荐培养基：平滑肌细胞培养基 (SMCM, Cat. #1101)
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货号
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3410
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产地
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美国
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缩写
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HTSMC
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规格
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5 x 10^5 /1ml
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用途
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科研
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储存
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液氮
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运输
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干冰
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关键字
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人气管平滑肌细胞 HTSMC 人气管平滑肌细胞 HTSMC 人气管平滑肌细胞 HTSMC 人气管平滑肌细胞 HTSMC 人气管平滑肌细胞 HTSMC 人气管平滑肌细胞 HTSMC 人气管平滑肌细胞 HTSMC 人气管平滑肌细胞 HTSMC
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公司简介
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合肥星肽生物科技有限公司作为专业的ScienCell中国代理商，专业经营实验室科研用原代细胞、原代细胞专用培养基、原代细胞无血清培养基、干细胞、干细胞培养基、干细胞无血清培养基的研究和开发。合肥星肽生物科技有限公司始终致力于为客户提供可靠的研究材料以及方便快捷的服务，对购买项目的前期资料提供,中期合同保证,后期货物跟踪到*终售后的确保项目准确到位，都有相关专业人士进行维护,确保您在合肥合肥星肽生物科技有限公司公司获得*上等服务！
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联系方式
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何经理，合肥星肽生物科技有限公司，Tel：0551-63802898 400-8702-898，
E-mail：info@qingbio.com http://www.qingbio.com QQ:514713116
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7.) Luo SF, Chang CC, Lee IT, Lee CW, Lin WN, Lin CC, Yang CM. (2009) "Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells."?Toxicol Appl Pharmacol. 237: 8-21.?
8.) Yang CM, Lee IT, Lin CC, Yang YL, Luo SF, Kou YR, Hsiao LD. (2009) "Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells."?Am J Physiol Lung Cell Mol Physiol. 297: L892-902.
9.) Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM. (2008) "Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells."?Mol Pharmacol. 73: 1454-64.
10.) Liang KC, Lee CW, Lin WN, Lin CC, Wu CB, Luo SF, Yang CM. (2007) "Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells."?J Cell Physiol. 211: 759-70.
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