心脏成纤维细胞为心肌细胞提供结构支持,并负责在生长和病理生理条件下心肌细胞外基质的合成。CF是心肌损伤反应的重要细胞成分和旁分泌生长因子的来源。CF的增殖和基质合成对于心肌梗塞、心肌纤维化部位瘢痕形成具有重要作用。CF的培养已被广泛应用为生理(运动)和病理(高血压)应激下心脏基质重塑研究的模型。CF的培养已被广泛应用为生理(运动)和病理(高血压)应激下心脏基质重塑研究的模型。CF通过间隙连接施加电紧张,影响心肌细胞的电耦合性形式。这些电耦合被认为在心房复杂的分流电描位点发生中起重要作用,因此是研究房颤的一个**模型。
Sciencell研究实验室的HCF-aa是从人胎儿心房分离得到的,原代冻存,冰冻运输。每管细胞密度超过5×10^5/ml。细胞特性经纤维粘连蛋白免疫荧光鉴定。本细胞经检测不含HIV-1、HBV、HCV、支原体、细菌、酵母菌和真菌。如采用ScienCell 实验室特制的培养基,可保证此细胞15倍增增殖。
推荐培养基:内皮细胞培养基 (HM, Cat. #2301)
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